Replacing Shox2 with human SHOX leads to congenital disc degeneration of the temporomandibular joint in mice
نویسندگان
چکیده
منابع مشابه
Overexpression of Shox2 Leads to Congenital Dysplasia of the Temporomandibular Joint in Mice
Our previous study reported that inactivation of Shox2 led to dysplasia and ankylosis of the temporomandibular joint (TMJ), and that replacing Shox2 with human Shox partially rescued the phenotype with a prematurely worn out articular disc. However, the mechanisms of Shox2 activity in TMJ development remain to be elucidated. In this study, we investigated the molecular and cellular basis for th...
متن کاملShox2-deficiency leads to dysplasia and ankylosis of the temporomandibular joint in mice
The temporomandibular joint (TMJ) is a unique synovial joint whose development differs from the formation of other synovial joints. Mutations have been associated with the developmental defects of the TMJ only in a few genes. In this study, we report the expression of the homeobox gene Shox2 in the cranial neural crest derived mesenchymal cells of the maxilla-mandibular junction and later in th...
متن کاملExpressing human SHOX in Shox2SHOX KI/KI mice leads to congenital osteoarthritis-like disease of the temporomandibular joint in postnatal mice
The temporomandibular joint (TMJ), a unique synovial joint whose development differs from that of other synovial joints, develops from two distinct mesenchymal condensations that grow toward each other and ossify through different mechanisms. The short stature homeobox 2 (Shox2) gene serves an important role in TMJ development and previous studies have demonstrated that Shox2SHOX KI/KI mice dis...
متن کاملTemporomandibular joint disc: a proposed histopathological degeneration grading score system.
AIMS The purpose of this study was to draw up a TMJ disc histopathological score that is a semi-quantitative transcription of the entire spectrum of TMJ disc degenerative diseases related to changes in disc tissue, and then validate the proposed grading, in order to contribute to a standardized histopathological diagnosis. METHODS Sections from sixty two temporomandibular joint disc specimens...
متن کاملTemporomandibular Joint Disc
temporomandibular disorders (TMD), because of its reversibility. The present study analyzed the effect of the articular disc position and occlusal splints use on the stress distribution on this disc. A two-dimensional (2D) finite element (FE) model of the temporomandibular joint with the articular disc at its physiologic position was constructed based on cone-beam computed tomography. Three oth...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell and Tissue Research
سال: 2013
ISSN: 0302-766X,1432-0878
DOI: 10.1007/s00441-013-1743-2